David Askin’s Chemistry Patents

David Askin has proven himself as a CMC drug development innovator over his more than 30 years in the industry. David has over 30 US patents and applications for chemistry processes and formulas pertaining to biotech/pharmaceutical drug development.

  1. R. Verhoeven and D. Askin, “Process for a-C-Alkylation of the 8-Acyl Group on Mevinolin and Analogs Thereof”, U.S. Patent #4,820,850 (ZOCOR® process patent).
  2. Askin, K.K. Eng, and R.P. Volante, “Process for Making HIV Protease Inhibitors, U.S. Patent #5,496,948 (Winner of NJ R&D Council’s Thomas Alva Edison Patent Award for CRIXIVAN®).
  3. Askin, R.A. Reamer, T.K. Jones, R.P. Volante and I. Shinkai, “Novel Hydroxide Mediated FK-506 Rearrangement Process”, U.S. Patent #4,920,218.
  4. Askin, R.A. Reamer, T.K. Jones, R.P. Volante and I. Shinkai, “Novel Hydroxide Mediated FK-506 Rearrangement Product”, U.S. Patent #4,980,466.
  5. P. Volante, D. Askin, I. Shinkai and K.M. Ryan “Process for the Synthesis of FK-506 Intermediates”, U.S. Patent #5,087,703.
  6. Askin, R.P. Volante, D. Joe and I. Shinkai, “New Synthetic Process for FK-506 Type Macrolide Intermediate”, U.S. Patent #5,164,525.
  7. Askin, R.P. Volante, M.A. Wallace and I. Shinkai; “Stereoselective Production of Hydroxyamide Compounds from Chiral -Amino Epoxides”, U.S. Patent #5,169,952.
  8. Askin, D. Joe, R.P. Volante and I. Shinkai,”FK-506 Type Macrolide Intermediate”, U.S. Patent #5,235,066.
  9. K. Jones, S.G. Mills, D. Askin, R. A. Reamer, R. Desmond, D.M. Tschaen, R.P. Volante, I. Shinkai, “Process for the Synthesis of FK-506 and Tricarbonyl Intermediates”, U.S. Patent #5,446,158.
  10. Askin, K. Eng, R.P. Volante, “Process for Making HIV Protease Inhibitors”, U.S. Patent #4,463,067.
  11. Askin, R. P. Volante, and K. Eng, “Process for Making HIV Protease Inhibitors”, U.S. Patent #5,491,238.
  12. Askin, S. Cianciosi, R. Hoerrner, “Reductive Amination Process”, U.S. Patent #5,508,404.
  13. Askin, J. Sager, K. Rossen, R. Volante and P. Reider, “Process for Making HIV Protease Inhibitors”, U.S. Patent #5,612,484.
  14. Askin, K. Eng, P. Reider and R. Volante, “Process to Make HIV Protease Inhibitor From (2S)-4-Picolyl-2-Piperazine-t-Butyl-Carboxamide”, U.S. Patent # 5,618,937.
  15. Askin, K. Wells, R. Varsolona, K. Rossen, R.P. Volante and P. Reider, “Process for Making HIV Protease Inhibitors”, U.S. Patent #5,618,939.
  16. Askin, P. Reider, K. Rossen, R. Varsolona, R. Volante, K. Wells, US Patent #5,637,711.
  17. Rossen, D. Askin, R. Varsolona, R.P. Volante and P. Reider, “Process for Racemization of (R)-2-piperazine-t-butylcarboxamide and Derivatives”, U.S. Patent #5,663,341.
  18. Askin, K. Rossen, P. Reider, R. Varsolona, R. Volante, K. Wells, “Process for Making HIV Protease Inhibitors”, U.S. Patent #5,693,803.
  19. Askin, K. Rossen, P. Reider, R. Varsolona, R. Volante, K. Wells, “Process for Making HIV Protease Inhibitors”, U.S. Patent #5,861,512.
  20. Askin, P. Maligres, M. Chartrain, R. Volante, “Process for the Preparation of (S)-3-Carbethoxy-3-Benzylpiperidine”, U.S. Patent #5,929,243.
  21. Askin, R. Purick, R. Hoerrner, P. Reider, R. Varsolona, R. Volante, “HIV Protease Inhibitor”, U.S. Patent #6,071,916.
  22. Askin, P. Maligres, J. McWilliams, M. Waters, “Process for Making 1,5-Disubstituted Imidazoles”, U.S. Patent #6,140,508.
  23. Askin, S. Lewis, S. Weissman, “Process for the Synthesis of Substituted piperazinones via Mitsunobu Reaction”, U.S. Patent #6,160,118.
  24. Askin, J. Cowen, P. Maligres, J. McWilliams, M. Waters, “Process for synthesizing biaryl inhibitors of farnesyl-protein transferase”, U.S. Patent #6,239,280.
  25. Askin et al, “Process for the synthesis of (2S)-phenyl-3-piperidone”, U.S. Patent #6,388,083.
  26. Tata, Chapman, Duffy, Kevin, Rano, Zhang, Kirk, Lu, Raghavan, Fletiz, Armstrong, Askin and Hoerrner, “Gamma-Hydroxy-2-(Fluoroalkyl-aminocarbonyl)-1-Piperazinepentanamides and Uses Thereof”, U.S. Patent #6,642,237.
  27. Askin, S. Hoerrner, R. Purick, P. Reider, R. Varsolona, R. Volante, “Sulfate Salt of an HIV Protease Inhibitor Having Improved Oral Absorption and Bioavailability”, PCT/US98/10633, WO98/54178.
  28. Palucki, D. Askin, V. Angelico, R. Wenslow, “Potassium Salt of an HIV Integrase Inhibitor”, PCT/US04/06968, Sept 21, 2006.
  29. D. Askin, C. Han, J. Lane, T. Remarchuk, S. Shakya, G. Sowell, K. Spencer, P. Stengel, P. Malen, “Process for Making Hydroxylated Cyclopentypyrimidine Compounds”, PCT/US13/41666, May 17, 2013.
  30. C. Han, G. Sowell, D. Askin, “Process for Making Hydroxylated Cyclopentylpyrimidine Compounds”, PCT/US2013/041666, 2013.